Imprimis Pharmaceuticals, Inc. has announced that it now has a customizable compounded formulation of pyrimethamine and leucovorin that physicians can possibly prescribe as a much lower cost alternative to Daraprim. While the price of Daraprim has gone up to $750 a tablet, Imprimis came up with pyrimethamine and leucovorin oral capsules that only cost $0.99 each.
Last month, Turing Pharmaceuticals LLC, the only supplier of Daraprim, decided to increase the price of the said prescription drug from $13.50 to $750 per tablet. According to its FDA-approved label, Daraprim is a drug prescribed for the treatment of toxoplasmosis as well as other types of infections.
According to the Centers for Disease Control and Prevention, toxopasmosis is a disease caused by being infected with the Toxoplasma gondii parasite. It can lead to serious problems, especially among pregnant women or those with compromised immune systems. Toxoplasmosis can be caused by the consumption of undercooked and/or contaminated meat or contaminated water.
As a treatment, the CDC prescribes pyrimethamine 100 mg for one day as a loading dose, followed by 25 to 50 mg per day. This dose has also be done in conjunction with 5 to 25 mg of leucovorin with each dose of pyrimethamine. This is because leucovorin will protect the bone marrow from toxic effects of the pyrimethamine.
Today, Imprimis now offers customizable compounded formulations of pyrimethamine and leucovorin in oral capsules that sell for $99 for a bottle of 100 capsules. Orders can be made by filling up Imprimis’ order form.